Early-pregnancy prediction of risk for pre-eclampsia using maternal blood leptin/ceramide ratio: discovery and confirmation.

ABSTRACT:

Objective

This study aimed to develop a blood test for the prediction of pre-eclampsia (PE) early in gestation. We hypothesised that the longitudinal measurements of circulating adipokines and sphingolipids in maternal serum over the course of pregnancy could identify novel prognostic biomarkers that are predictive of impending event of PE early in gestation.

Study design

Retrospective discovery and longitudinal confirmation.

Setting

Maternity units from two US hospitals.

Participants

Six previously published studies of placental tissue (78 PE and 95 non-PE) were compiled for genomic discovery, maternal sera from 15 women (7 non-PE and 8 PE) enrolled at ProMedDx were used for sphingolipidomic discovery, and maternal sera from 40 women (20 non-PE and 20 PE) enro

SUBMITTER: Huang Q 

PROVIDER: S-EPMC8627403 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature