Rapid simultaneous acquisition of macromolecular tissue volume, susceptibility, and relaxometry maps.

ABSTRACT:

Purpose

A major obstacle to the clinical implementation of quantitative MR is the lengthy acquisition time required to derive multi-contrast parametric maps. We sought to reduce the acquisition time for QSM and macromolecular tissue volume by acquiring both contrasts simultaneously by leveraging their redundancies. The joint virtual coil concept with GRAPPA (JVC-GRAPPA) was applied to reduce acquisition time further.

Methods

Three adult volunteers were imaged on a 3 Tesla scanner using a multi-echo 3D GRE sequence acquired at 3 head orientations. Macromolecular tissue volume, QSM, R2∗ , T₁ , and proton density maps were reconstructed. The same sequence (GRAPPA R = 4) was performed in subject 1 with a single head orientation for comparison. Fully sampled data was a

SUBMITTER: Yu FF 

PROVIDER: S-EPMC8627440 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature