Strategies for late phase preclinical and early clinical trials of senolytics.

ABSTRACT: Cellular senescence and the hallmarks of aging contribute to age-related disease and dysfunction. The Unitary Theory of Fundamental Aging Mechanisms highlights the interdependence among the hallmarks of aging and suggests that by intervening in one fundamental aging process, most or all of the other processes could be impacted. Accumulation of senescent cells is associated with frailty, cardiovascular disease, obesity, diabetes, cognitive decline, and other age- and/or chronic disease-related disorders, suggesting that senescent cells are a target for intervention. Early preclinical data using senolytics, agents that target senescent cells, show promising results in several aging and disease models. The first in-human trials using the senolytic combination of Dasatinib and Quercetin indica

SUBMITTER: Wissler Gerdes EO 

PROVIDER: S-EPMC8627448 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature