Consistent depiction of the acidic ischemic lesion with APT MRI-Dual RF power evaluation of pH-sensitive image in acute stroke.

ABSTRACT:

Purpose

Amide proton transfer-weighted (APTw) MRI provides a non-invasive pH-sensitive image, complementing perfusion and diffusion imaging for refined stratification of ischemic tissue. Although the commonly used magnetization transfer (MT) asymmetry (MTR_asym ) calculation reasonably corrects the direct RF saturation effect, it is susceptible to the concomitant semisolid macromolecular MT contribution. Therefore, this study aimed to compare the performance of MTR_asym and magnetization transfer and relaxation-normalized APT (MRAPT) analyses under 2 representative experimental conditions.

Methods

Multiparametric MRI scans were performed in a rodent model of acute stroke, including relaxation, diffusion, and Z spectral images under 2 representative RF lev

SUBMITTER: Sun PZ 

PROVIDER: S-EPMC8627494 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature