Environmental effects on acute exacerbations of respiratory diseases: A real-world big data study.

ABSTRACT:

Background

The effects of weather periods, race/ethnicity, and sex on environmental triggers for respiratory exacerbations are not well understood. This study linked the OneFlorida network (~15 million patients) with an external exposome database to analyze environmental triggers for asthma, bronchitis, and COPD exacerbations while accounting for seasonality, sex, and race/ethnicity.

Methods

This is a case-crossover study of OneFlorida database from 2012 to 2017 examining associations of asthma, bronchitis, and COPD exacerbations with exposures to heat index, PM 2.5 and O 3. We spatiotemporally linked exposures using patients' residential addresses to generate average exposures during hazard and control periods, with each case serving as its own control. We considered age, s

SUBMITTER: Fishe J 

PROVIDER: S-EPMC8627495 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature