Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography.

ABSTRACT: Preclinical studies have implicated kappa opioid receptors (KORs) in stress responses and depression-related behaviors, but evidence from human studies is limited. Here we present results of a secondary analysis of data acquired using positron emission tomography (PET) with the KOR radiotracer [¹¹C]GR103545 in 10 unmedicated, currently depressed individuals with major depressive disorder (MDD; 32.6 ± 6.5 years, 5 women) and 13 healthy volunteers (34.8 ± 10 years, 6 women). Independent component analysis was performed to identify spatial patterns of coherent variance in KOR binding (tracer volume of distribution, V_T) across all subjects. Expression of each component was compared between groups and relationships to symptoms were explored using the 17-item Hamilton Depre

SUBMITTER: Smart K 

PROVIDER: S-EPMC8627509 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature