Metabolomic markers predictive of hepatic adaptation to therapeutic dosing of acetaminophen.

ABSTRACT:

Background

Drug induced liver injury (DILI) remains a prominent global issue and acetaminophen (APAP) overdose represents a common cause of hepatic injury and DILI. Transient alanine aminotransferase (ALT) elevations have been documented while adhering to recommended daily dosing. However, no metabolites have been identified in pre-treatment samples predicting which patients will develop these transient increases.

Methods

This was a secondary analysis of samples collected from a parent study describing the course of ALT levels in subjects receiving therapeutic APAP dosing. Two hundred and four subjects recruited from Denver, Colorado received 4 g APAP/daily for at least 16 days. Subjects were grouped by ALT at any monitored time point above 60 units/L (n = 25) vs. no

SUBMITTER: Sonn BJ 

PROVIDER: S-EPMC8627525 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature