A new phenotypic classification system for dyslipidemias based on the standard lipid panel.

ABSTRACT:

Background

Dyslipoproteinemias can be classified by their distinct lipoprotein patterns, which helps determine atherosclerotic cardiovascular disease (ASCVD) risk and directs lipid management but this has required advanced laboratory testing.

Objective

To develop a new algorithm for classifying lipoprotein disorders that only relies on the standard lipid panel.

Methods

Lipid thresholds for defining the different lipoprotein phenotypes were derived for Non-High-Density Lipoprotein-Cholesterol (NonHDL-C) and Triglycerides (TG) to be concordant when possible with the current US Multi-Society guidelines for blood cholesterol management.

Results

The new classification method categorizes patients into all the classical Fredrickson-like phenotypes except for Type III

SUBMITTER: Sampson M 

PROVIDER: S-EPMC8627634 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature