Elevated Aortic Pulse Wave Velocity Relates to Longitudinal Gray and White Matter Changes.

ABSTRACT:

Objective

To determine whether baseline aortic stiffness, measured by aortic pulse wave velocity (PWV), relates to longitudinal cerebral gray or white matter changes among older adults. Baseline cardiac magnetic resonance imaging will be used to assess aortic PWV while brain magnetic resonance imaging will be used to assess gray matter and white matter hyperintensity (WMH) volumes at baseline, 18 months, 3 years, 5 years, and 7 years. Approach and Results: Aortic PWV (m/s) was quantified from cardiac magnetic resonance. Multimodal 3T brain magnetic resonance imaging included T₁-weighted imaging for quantifying gray matter volumes and T₂-weighted fluid-attenuated inversion recovery imaging for quantifying WMHs. Mixed-effects regressi

SUBMITTER: Bown CW 

PROVIDER: S-EPMC8627676 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature