Multimodal neural recordings with Neuro-FITM uncover diverse patterns of cortical-hippocampal interactions.

ABSTRACT: Many cognitive processes require communication between the neocortex and the hippocampus. However, coordination between large-scale cortical dynamics and hippocampal activity is not well understood, partially due to the difficulty in simultaneously recording from those regions. In the present study, we developed a flexible, insertable and transparent microelectrode array (Neuro-FITM) that enables investigation of cortical-hippocampal coordinations during hippocampal sharp-wave ripples (SWRs). Flexibility and transparency of Neuro-FITM allow simultaneous recordings of local field potentials and neural spiking from the hippocampus during wide-field calcium imaging. These experiments revealed that diverse cortical activity patterns accompanied SWRs and, in most cases, cortical activation prec

SUBMITTER: Liu X 

PROVIDER: S-EPMC8627685 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature