Predicting Disease Recurrence, Early Progression, and Overall Survival Following Surgical Resection for High-risk Localized and Locally Advanced Renal Cell Carcinoma.

ABSTRACT:

Background

Risk stratification for localized renal cell carcinoma (RCC) relies heavily on retrospective models, limiting their generalizability to contemporary cohorts.

Objective

To introduce a contemporary RCC prognostic model, developed using prospective, highly annotated data from a phase III adjuvant trial.

Design, setting, and participants

The model utilizes outcome data from the ECOG-ACRIN 2805 (ASSURE) RCC trial.

Outcome measurements and statistical analysis

The primary outcome for the model is disease-free survival (DFS), with overall survival (OS) and early disease progression (EDP) as secondary outcomes. Model performance was assessed using discrimination and calibration tests.

Results and limitations

A total of 1735 patients were included in t

SUBMITTER: Correa AF 

PROVIDER: S-EPMC8627688 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature