Multistage hematopoietic stem cell regulation in the mouse: A combined biological and mathematical approach.

ABSTRACT: We have reconciled steady-state and stress hematopoiesis in a single mathematical model based on murine in vivo experiments and with a focus on hematopoietic stem and progenitor cells. A phenylhydrazine stress was first applied to mice. A reduced cell number in each progenitor compartment was evidenced during the next 7 days through a drastic level of differentiation without proliferation, followed by a huge proliferative response in all compartments including long-term hematopoietic stem cells, before a return to normal levels. Data analysis led to the addition to the 6-compartment model, of time-dependent regulation that depended indirectly on the compartment sizes. The resulting model was finely calibrated using a stochastic optimization algorithm and could reproduce biological d

SUBMITTER: Bonnet C 

PROVIDER: S-EPMC8627979 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature