Elastase Activity From Pseudomonas aeruginosa Respiratory Isolates and ICU Mortality.

ABSTRACT:

Background

Pseudomonas aeruginosa (PA) is a common cause of respiratory infection and morbidity. Pseudomonas elastase is an important virulence factor regulated by the lasR gene. Whether PA elastase activity is associated with worse clinical outcomes in ICU patients is unknown.

Research question

Is there an association between PA elastase activity and worse host outcomes in a cohort of ICU patients?

Methods

PA respiratory isolates from 238 unique ICU patients from two tertiary-care centers within the University of Pittsburgh Medical Center health system were prospectively collected and screened for total protease and elastase activity, biofilm production, antimicrobial resistance, and polymicrobial status. The association between pathogen characteristics and 30-day an

SUBMITTER: Zupetic J 

PROVIDER: S-EPMC8628173 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature