Mucociliary Clearance Differs in Mild Asthma by Levels of Type 2 Inflammation.

ABSTRACT:

Background

Although mucus plugging is a well-reported feature of asthma, whether asthma and type 2 inflammation affect mucociliary clearance (MCC) is unknown.

Research question

Does type 2 inflammation influence mucus clearance rates in patients with mild asthma who are not receiving corticosteroids?

Study design and methods

The clearance rates of inhaled radiolabeled particles were compared between patients with mild asthma with low (n = 17) and high (n = 18) levels of T2 inflammation. Fraction exhaled nitric oxide (Feno) was used to prospectively segregate subjects into T2 Lo (Feno < 25 ppb) and T2 Hi (Feno > 35 ppb) cohorts. Bronchial brush samples were collected with fiber-optic bronchoscopy, and quantitative polymerase chain reaction was performed to measure expr

SUBMITTER: Corcoran TE 

PROVIDER: S-EPMC8628176 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature