Timing of dialysis initiation to reduce mortality and cardiovascular events in advanced chronic kidney disease: nationwide cohort study.

ABSTRACT:

Objective

To identify the optimal estimated glomerular filtration rate (eGFR) at which to initiate dialysis in people with advanced chronic kidney disease.

Design

Nationwide observational cohort study.

Setting

National Swedish Renal Registry of patients referred to nephrologists.

Participants

Patients had a baseline eGFR between 10 and 20 mL/min/1.73 m² and were included between 1 January 2007 and 31 December 2016, with follow-up until 1 June 2017.

Main outcome measures

The strict design criteria of a clinical trial were mimicked by using the cloning, censoring, and weighting method to eliminate immortal time bias, lead time bias, and survivor bias. A dynamic marginal structural model was used to estimate adjusted hazard ratios and absolute ri

SUBMITTER: Fu EL 

PROVIDER: S-EPMC8628190 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature