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Comprehensive phenotyping of endothelial cells using flow cytometry 2: Human.


ABSTRACT: In vascular research, clinical samples and samples from animal models are often used together to foster translation of preclinical findings to humans. General concepts of endothelia and murine-specific endothelial phenotypes were discussed in part 1 of this two part series. Here, in part 2, we present a comprehensive overview of human-specific endothelial phenotypes. Pan-endothelial cell markers, organ specific endothelial antigens, and flow cytometric immunophenotyping of blood-borne endothelial cells are reviewed.

SUBMITTER: Grant D 

PROVIDER: S-EPMC8628257 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Comprehensive phenotyping of endothelial cells using flow cytometry 2: Human.

Grant Dillon D   Wanner Nicholas N   Frimel Matthew M   Erzurum Serpil S   Asosingh Kewal K  

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20201223 3


In vascular research, clinical samples and samples from animal models are often used together to foster translation of preclinical findings to humans. General concepts of endothelia and murine-specific endothelial phenotypes were discussed in part 1 of this two part series. Here, in part 2, we present a comprehensive overview of human-specific endothelial phenotypes. Pan-endothelial cell markers, organ specific endothelial antigens, and flow cytometric immunophenotyping of blood-borne endothelia  ...[more]

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