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Dilithium Amides as a Modular Bis-Anionic Ligand Platform for Iron-Catalyzed Cross-Coupling.

ABSTRACT: Dilithium amides have been developed as a bespoke and general ligand for iron-catalyzed Kumada-Tamao-Corriu cross-coupling reactions, their design taking inspiration from previous mechanistic and structural studies. They allow for the cross-coupling of alkyl Grignard reagents with sp²-hybridized electrophiles as well as aryl Grignard reagents with sp³-hybridized electrophiles. This represents a rare example of a single iron-catalyzed system effective across diverse coupling reactions without significant modification of the catalytic protocol, as well as remaining operationally simple.

SUBMITTER: Neate PGN

PROVIDER: S-EPMC8628259 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Dilithium Amides as a Modular Bis-Anionic Ligand Platform for Iron-Catalyzed Cross-Coupling.

Neate Peter G N PGN Zhang Bufan B Conforti Jessica J Brennessel William W WW Neidig Michael L ML

Organic letters 20210726 15

Dilithium amides have been developed as a bespoke and general ligand for iron-catalyzed Kumada-Tamao-Corriu cross-coupling reactions, their design taking inspiration from previous mechanistic and structural studies. They allow for the cross-coupling of alkyl Grignard reagents with sp<sup>2</sup>-hybridized electrophiles as well as aryl Grignard reagents with sp<sup>3</sup>-hybridized electrophiles. This represents a rare example of a single iron-catalyzed system effective across diverse coupling ...[more]

PMID: 34310141

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