Cooperative regulation of endocytic vesicle transport by yeast Eps15-like protein Pan1p and epsins.

ABSTRACT: Dynamic actin filaments are required for the formation and internalization of endocytic vesicles. Yeast actin cables serve as a track for the translocation of endocytic vesicles to early endosomes, but the molecular mechanisms regulating the interaction between vesicles and the actin cables remain ambiguous. Previous studies have demonstrated that the yeast Eps15-like protein Pan1p plays an important role in this interaction, and that interaction is not completely lost even after deletion of the Pan1p actin-binding domain, suggesting that additional proteins mediate association of the vesicle with the actin cable. Other candidates for mediating the interaction are endocytic coat proteins Sla2p (yeast Hip1R) and Ent1p/2p (yeast epsins), as these proteins can bind to both the plasma membrane

SUBMITTER: Yoshida N 

PROVIDER: S-EPMC8628263 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature