MGlu₁ potentiation enhances prelimbic somatostatin interneuron activity to rescue schizophrenia-like physiological and cognitive deficits.

ABSTRACT: Evidence for prefrontal cortical (PFC) GABAergic dysfunction is one of the most consistent findings in schizophrenia and may contribute to cognitive deficits. Recent studies suggest that the mGlu₁ subtype of metabotropic glutamate receptor regulates cortical inhibition; however, understanding the mechanisms through which mGlu₁ positive allosteric modulators (PAMs) regulate PFC microcircuit function and cognition is essential for advancing these potential therapeutics toward the clinic. We report a series of electrophysiology, optogenetic, pharmacological magnetic resonance imaging, and animal behavior studies demonstrating that activation of mGlu₁ receptors increases inhibitory transmission in the prelimbic PFC by selective excitation of somatostatin-expres

SUBMITTER: Maksymetz J 

PROVIDER: S-EPMC8628371 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature