Modified Diffusion Tensor Image Processing Pipeline for Archived Studies of Patients With Leukoencephalopathy.

ABSTRACT:

Background

In archived diffusion tensor imaging (DTI) studies, a reversed-phase encoding (PE) scan required to correct the distortion in single-shot echo-planar imaging (EPI) may not have been acquired. Furthermore, DTI tractography is adversely affected by incorrect white matter segmentation due to leukoencephalopathy (LE). All these issues need to be addressed.

Purpose

To propose and evaluate a modified DTI processing pipeline with DIstortion COrrection using pseudo T₂ -weighted images (DICOT) to overcome limitations in existing acquisition protocols.

Study type

Retrospective feasibility.

Subjects

DICOT was assessed in simulated data and 84 acute lymphoblastic leukemia (ALL) patients with reversed PE acquired. The pipeline was then tested in 522 sc

SUBMITTER: Song R 

PROVIDER: S-EPMC8628478 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature