Genetics & Epigenetics of Hereditary Deafness: An Historical Overview.

ABSTRACT: Hearing loss (HL) is one of the most common sensory impairments worldwide and represents a critical medical and public health issue. Since the mid-1900s, great efforts have been aimed at understanding the etiology of both syndromic and non-syndromic HL and identifying correlations with specific audiological phenotypes. The extraordinary discoveries in the field of molecular genetics during the last three decades have contributed substantially to the current knowledge. Next-generation sequencing technologies have dramatically increased the diagnostic rate for genetic HL, enabling the detection of novel variants in known deafness-related genes and the discovery of new genes implicated in hearing disease. Overall, genetic factors account for at least 40% of the cases with HL, but a portion of

SUBMITTER: Martini A 

PROVIDER: S-EPMC8628574 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature