The influence of storage time on ponazuril concentrations in feline plasma.

ABSTRACT:

Background

The pharmacokinetics of ponazuril have been determined in several species; however, there is very little information on the stability of the drug after storage for long periods of time. This study was undertaken to determine the stability of ponazuril in plasma samples stored at -80 °C, which is the temperature most commonly used in the author's laboratory.

Method

Spiked plasma samples (0.3, 7.5, and 15 µg/mL) were stored at -80 °C for three months. Analysis occurred on the first day and then once a week for the following twelve weeks. The drug was extracted using a chloroform extraction and separated by high performance liquid chromatography using ultraviolet detection.

Results

There was no loss of drug for any concentration for the first four weeks of sto

SUBMITTER: Cox S 

PROVIDER: S-EPMC8628618 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature