Helicobacter pylori virulence factors: relationship between genetic variability and phylogeographic origin.

ABSTRACT:

Background

Helicobacter pylori is a pathogenic bacteria that colonize the gastrointestinal tract from human stomachs and causes diseases including gastritis, peptic ulcers, gastric lymphoma (MALT), and gastric cancer, with a higher prevalence in developing countries. Its high genetic diversity among strains is caused by a high mutation rate, observing virulence factors (VFs) variations in different geographic lineages. This study aimed to postulate the genetic variability associated with virulence factors present in the Helicobacter pylori strains, to identify the relationship of these genes with their phylogeographic origin.

Methods

The complete genomes of 135 strains available in NCBI, from different population origins, were analyzed using bioinformatics tool

SUBMITTER: Rodriguez AM 

PROVIDER: S-EPMC8628625 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature