Functionalized Nanocellulose Drives Neural Stem Cells toward Neuronal Differentiation.

ABSTRACT: Transplantation of differentiated and fully functional neurons may be a better therapeutic option for the cure of neurodegenerative disorders and brain injuries than direct grafting of neural stem cells (NSCs) that are potentially tumorigenic. However, the differentiation of NSCs into a large population of neurons has been a challenge. Nanomaterials have been widely used as substrates to manipulate cell behavior due to their nano-size, excellent physicochemical properties, ease of synthesis, and versatility in surface functionalization. Nanomaterial-based scaffolds and synthetic polymers have been fabricated with topology resembling the micro-environment of the extracellular matrix. Nanocellulose materials are gaining attention because of their availability, biocompatibility, biodegradabil

SUBMITTER: Pandanaboina SC 

PROVIDER: S-EPMC8628960 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature