Developing a Food Exposure and Urine Sampling Strategy for Dietary Exposure Biomarker Validation in Free-Living Individuals.

ABSTRACT:

Scope

Dietary choices modulate the risk of chronic diseases and improving diet is a central component of public health strategies. Food-derived metabolites present in urine could provide objective biomarkers of dietary exposure. To assist biomarker validation, this work aims to develop a food intervention strategy mimicking a typical annual diet over a short period of time and assesses urine sampling protocols potentially suitable for future deployment of biomarker technology in free-living populations.

Methods and results

Six different menu plans comprehensively represent a typical UK annual diet that is split into two dietary experimental periods. Free-living adult participants (n = 15 and n = 36, respectively) are provided with all their food, as a series of menu plans, o

SUBMITTER: Lloyd AJ 

PROVIDER: S-EPMC8629115 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature