Protocol: Benefits and harms of remdesivir for COVID-19 in adults: A systematic review with meta-analysis.

ABSTRACT:

Background

Effective drug treatments for Covid-19 are needed to decrease morbidity and mortality for the individual and to alleviate pressure on health care systems. Remdesivir showed promising results in early randomised trials but subsequently a large publicly funded trial has shown less favourable results and the evidence is interpreted differently in clinical guidelines. Systematic reviews of remdesivir have been published, but none have systematically searched for unpublished data, including regulatory documents, and assessed the risk of bias due to missing evidence.

Methods

We will conduct a systematic review of randomised trials comparing remdesivir to placebo or standard of care in any setting. We will include trials regardless of the severity of disease and we will

SUBMITTER: Paludan-Muller AS 

PROVIDER: S-EPMC8629254 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature