Longer duration of statin therapy is associated with decreased carotid plaque vascularity by magnetic resonance imaging.

ABSTRACT:

Objective

Plaque neovasculature is a major route for lipoprotein and leukocyte ingress into plaques, and has been identified as a risk factor for carotid plaque disruption. Vp, a variable derived from pharmacokinetic modeling of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), correlates with plaque neovasculature density. Because lipid-lowering therapy has been associated with regression of neovasculature in animal models, we sought to determine clinical correlates of carotid plaque neovasculature (as assessed by Vp) in participants on statin therapy for established cardiovascular disease.

Methods

98 participants from an AIM-HIGH sub-study underwent DCE-MRI of their carotid arteries. Expert readers who were blinded to all clinical variables analyzed the MR im

SUBMITTER: O'Brien KD 

PROVIDER: S-EPMC8629315 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature