The gammaherpesvirus 68 viral cyclin facilitates expression of LANA.

ABSTRACT: Gammaherpesviruses establish life-long infections within their host and have been shown to be the causative agents of devastating malignancies. Chronic infection within the host is mediated through cycles of transcriptionally quiescent stages of latency with periods of reactivation into detectable lytic and productive infection. The mechanisms that regulate reactivation from latency remain poorly understood. Previously, we defined a critical role for the viral cyclin in promoting reactivation from latency. Disruption of the viral cyclin had no impact on the frequency of cells containing viral genome during latency, yet it remains unclear whether the viral cyclin influences latently infected cells in a qualitative manner. To define the impact of the viral cyclin on properties of latent infe

SUBMITTER: Niemeyer BF 

PROVIDER: S-EPMC8629379 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature