The genome variation and developmental transcriptome maps reveal genetic differentiation of skeletal muscle in pigs.

ABSTRACT: Natural and artificial directional selections have resulted in significantly genetic and phenotypic differences across breeds in domestic animals. However, the molecular regulation of skeletal muscle diversity remains largely unknown. Here, we conducted transcriptome profiling of skeletal muscle across 27 time points, and performed whole-genome re-sequencing in Landrace (lean-type) and Tongcheng (obese-type) pigs. The transcription activity decreased with development, and the high-resolution transcriptome precisely captured the characterizations of skeletal muscle with distinct biological events in four developmental phases: Embryonic, Fetal, Neonatal, and Adult. A divergence in the developmental timing and asynchronous development between the two breeds was observed; Landrace showed a dev

SUBMITTER: Yang Y 

PROVIDER: S-EPMC8629385 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature