Ontology highlight
ABSTRACT:
SUBMITTER: Paracchini L
PROVIDER: S-EPMC8629406 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Paracchini Lara L Mannarino Laura L Craparotta Ilaria I Romualdi Chiara C Fruscio Robert R Grassi Tommaso T Fotia Vittoria V Caratti Giulia G Perego Patrizia P Calura Enrica E Clivio Luca L D'Incalci Maurizio M Beltrame Luca L Marchini Sergio S
Oncotarget 20160709 24
Stage III/IV epithelial ovarian cancer (EOC) is a systemic disease. The clonal relationship among different tumor lesions at diagnosis (spatial heterogeneity) and how tumor clonal architecture evolves over time (temporal heterogeneity) have not yet been defined. Such knowledge would help to develop new target-based strategies, as biomarkers which can adjudge the success of therapeutic intervention should be independent of spatial and temporal heterogeneity. The work described in this paper addre ...[more]