Molecular Landscape and Computational Screening of the Natural inhibitors against HPV16 E6 Oncoprotein.

ABSTRACT:

Background

Human Papillomavirus (HPV) is a small, non-enveloped, icosahedral and double-stranded DNA virus with a genome of 8 kb, belonging to the papillomaviridae family. HPV has been associated with 99.7% cases of cervical squamous cell carcinoma worldwide. The HPV E6 protein is known as a potent oncogene and is closely allied with the events that result in the malignant transformation of virally infected cells.

Objective

The present study aims to target plant derived anticancer molecules for HPV driven cancer using a computational approach.

Methods

In this study, E6 oncoprotein was targeted by 101 plant-derived nutraceuticals using the molecular docking method. The multiple sequence analysis and phylogenetic analysis of low risk and high risk 28 HPV E6 proteins wer

SUBMITTER: Juneja T 

PROVIDER: S-EPMC8629474 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature