Impact of personal genomic risk information on melanoma prevention behaviors and psychological outcomes: a randomized controlled trial.

ABSTRACT:

Purpose

We evaluated the impact of personal melanoma genomic risk information on sun-related behaviors and psychological outcomes.

Methods

In this parallel group, open, randomized controlled trial, 1,025 Australians of European ancestry without melanoma and aged 18-69 years were recruited via the Medicare database (3% consent). Participants were randomized to the intervention (n = 513; saliva sample for genetic testing, personalized melanoma risk booklet based on a 40-variant polygenic risk score, telephone-based genetic counseling, educational booklet) or control (n = 512; educational booklet). Wrist-worn ultraviolet (UV) radiation dosimeters (10-day wear) and questionnaires were administered at baseline, 1 month postintervention, and 12 months postbaseline.

Results

SUBMITTER: Smit AK 

PROVIDER: S-EPMC8629758 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature