The marriage of chemokines and galectins as functional heterodimers.

ABSTRACT: Trafficking of leukocytes and their local activity profile are of pivotal importance for many (patho)physiological processes. Fittingly, microenvironments are complex by nature, with multiple mediators originating from diverse cell types and playing roles in an intimately regulated manner. To dissect aspects of this complexity, effectors are initially identified and structurally characterized, thus prompting familial classification and establishing foci of research activity. In this regard, chemokines present themselves as role models to illustrate the diversification and fine-tuning of inflammatory processes. This in turn discloses the interplay among chemokines, their cell receptors and cognate glycosaminoglycans, as well as their capacity to engage in new molecular interactions that for

SUBMITTER: von Hundelshausen P 

PROVIDER: S-EPMC8629806 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature