IL4Rα signaling promotes neonatal cardiac regeneration and cardiomyocyte cell cycle activity.

ABSTRACT: Neonatal heart regeneration depends on proliferation of pre-existing cardiomyocytes, yet the mechanisms driving regeneration and cardiomyocyte proliferation are not comprehensively understood. We recently reported that the anti-inflammatory cytokine, interleukin 13 (IL13), promotes neonatal cardiac regeneration; however, the signaling pathway and cell types mediating this regenerative response remain unknown. Here, we hypothesized that expression of the type II heterodimer receptor for IL13, comprised of IL4Rα and IL13Rα1, expressed directly on cardiomyocytes mediates cardiomyocyte cell cycle and heart regeneration in neonatal mice. Our data demonstrate that indeed global deletion of one critical subunit of the type II receptor, IL4Rα (IL4Rα^-/-), decreases cardiomyocyte prolifer

SUBMITTER: Paddock SJ 

PROVIDER: S-EPMC8629844 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature