Individual localization value of resting-state fMRI in epilepsy presurgical evaluation: A combined study with stereo-EEG.

ABSTRACT:

Objective

To examine the individual-patient-level localization value of resting-state functional MRI (rsfMRI) metrics for the seizure onset zone (SOZ) defined by stereo-electroencephalography (SEEG) in patients with medically intractable focal epilepsies.

Methods

We retrospectively included 19 patients who underwent SEEG implantation for epilepsy presurgical evaluation. Voxel-wise whole-brain analysis was performed on 3.0 T rsfMRI to generate clusters for amplitude of low-frequency fluctuations (ALFF), regional homogeneity (ReHo) and degree centrality (DC), which were co-registered with the SEEG-defined SOZ to evaluate their spatial overlap. Subgroup and correlation analyses were conducted for various clinical characteristics.

Results

ALFF demonstrated concordant clus

SUBMITTER: Tang Y 

PROVIDER: S-EPMC8629929 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature