Reduced bone mineral density in the first year after total pancreatectomy with islet autotransplantation (TPIAT).

ABSTRACT:

Background/objectives

The effect of total pancreatectomy with islet autotransplantation (TPIAT) on bone mineral density (BMD) in patients with CP is unknown. We aimed to assess bone health in patients with CP after TPIAT.

Methods

We measured BMD, BMD Z-score, and bone mineral content (BMC) for total body, lumbar spine, right and left hip in 78 patients before and after TPIAT using dual-energy X-ray absorptiometry (DXA, n = 78 pre-TPIAT, n = 65 paired pre- and 12 months post-TPIAT, n = 33 paired 12 and 18 months post-TPIAT), and tested for association with clinical history including age, smoking status, and medications using paired and two-sample t-tests, linear regression, and Fisher's exact test. Laboratory measures related to bone health were also assessed.

Results

SUBMITTER: Wothe JK 

PROVIDER: S-EPMC8629939 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature