MICU3 regulates mitochondrial Ca²⁺-dependent antioxidant response in skeletal muscle aging.

ABSTRACT: Age-related loss of skeletal muscle mass and function, termed sarcopenia, could impair the quality of life in the elderly. The mechanisms involved in skeletal muscle aging are intricate and largely unknown. However, more and more evidence demonstrated that mitochondrial dysfunction and apoptosis also play an important role in skeletal muscle aging. Recent studies have shown that mitochondrial calcium uniporter (MCU)-mediated mitochondrial calcium affects skeletal muscle mass and function by affecting mitochondrial function. During aging, we observed downregulated expression of mitochondrial calcium uptake family member3 (MICU3) in skeletal muscle, a regulator of MCU, which resulted in a significant reduction in mitochondrial calcium uptake. However, the role of MICU3 in skeletal muscle agi

SUBMITTER: Yang YF 

PROVIDER: S-EPMC8630021 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature