Patterns of tau pathology identified with ¹⁸ F-MK-6240 PET imaging.

ABSTRACT:

Introduction

Positron emission tomography (PET) imaging for neurofibrillary tau allows investigation of the in vivo spatiotemporal progression of Alzheimer's disease (AD) pathology. We evaluated the suitability of ¹⁸ F-MK-6240 in a clinical sample and determined the relationships among ¹⁸ F-MK-6240 binding, age, cognition, and cerebrospinal fluid (CSF)-based AD biomarkers.

Methods

Participants (n = 101, 72 ± 9 years, 52% women) underwent amyloid PET, tau PET, structural T1-weighted magnetic resonance imaging, and neuropsychological evaluation. Twenty-one participants had lumbar puncture for CSF measurement of amyloid beta (Aβ)₄₂ , tau, and phosphorylated tau (p-tau).

Results

¹⁸ F-MK-6240 recapitulated Braak staging and corre

SUBMITTER: Kreisl WC 

PROVIDER: S-EPMC8630090 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature