A randomized double-blind placebo controlled pilot study of probiotics in adolescents with severe obesity.

ABSTRACT:

Purpose

The purpose of the study is to assess the effect of probiotic supplementation on gut microbiota and insulin resistance in adolescents with severe obesity.

Methods

Through a randomized, double blind, placebo-controlled, 12-week pilot clinical trial, 15 adolescents with severe obesity received either an oral probiotic 'Visbiome®' (n = 8) or placebo (n = 7). Anthropometry, fasting glucose, insulin, hs-CRP and stool for microbiome and calprotectin were collected at baseline (week 0) and 12 weeks after intervention.

Results

Among completers (n = 4 in each of the two groups), mean change in fasting glucose was significantly lower in the probiotic group (0 ± 4 mg/dL) as compared to the placebo group (6.3 ± 1.7 mg/dL) (p = 0.028). Gut micro

SUBMITTER: Verma A 

PROVIDER: S-EPMC8630143 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature