Angiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs.

ABSTRACT: Paternal environmental inputs can influence various phenotypes in offspring, presenting tremendous implications for basic biology and public health and policy. However, which signals function as a nexus to transmit paternal environmental inputs to offspring remains unclear. Here we show that offspring of fathers with inflammation exhibit metabolic disorders including glucose intolerance and obesity. Deletion of a mouse tRNA RNase, Angiogenin (Ang), abolished paternal inflammation-induced metabolic disorders in offspring. Additionally, Ang deletion prevented the inflammation-induced alteration of 5'-tRNA-derived small RNAs (5'-tsRNAs) expression profile in sperm, which might be essential in composing a sperm RNA 'coding signature' that is needed for paternal epigenetic memory. Microinjectio

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8630171 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature