A systematic review of miRNAs as biomarkers in osteoporosis disease.

ABSTRACT:

Background

Osteoporosis is often considered to be a disease of the elderly, which is characterized by two characteristics: low bone mineral density (BMD) and increased risk of fracture. MicroRNAs (miRNAs) have been reported to play a potential role in bone formation and resorption, bone remodeling, bone homeostasis regulation, and bone cell differentiation. Therefore, altered expression of different miRNAs may impact the pathology of bone diseases such as osteoporosis. A systematic review was conducted to extract all miRNA found to be significantly dys-regulated in the peripheral blood.

Methods

This review was carried out using a systematically search on PubMed, Scopus, Embase, Web of Science (WoS), and Cochrane databases from 1990 to 2018 to explore the diagnostic value of

SUBMITTER: Hasanzad M 

PROVIDER: S-EPMC8630174 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature