Shear-Mediated Platelet Activation is Accompanied by Unique Alterations in Platelet Release of Lipids.

ABSTRACT:

Introduction

Platelet activation by mechanical means such as shear stress exposure, is a vital driver of thrombotic risk in implantable blood-contacting devices used in the treatment of heart failure. Lipids are essential in platelets activation and have been studied following biochemical activation. However, little is known regarding lipid alterations occurring with mechanical shear-mediated platelet activation.

Methods

Here, we determined if shear-activation of platelets induced lipidome changes that differ from those associated with biochemically-mediated platelet activation. We performed high-resolution lipidomic analysis on purified platelets from four healthy human donors. For each donor, we compared the lipidome of platelets that were non-activated or activated by she

SUBMITTER: Sweedo A 

PROVIDER: S-EPMC8630256 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature