Prognostic Significance of Signet Ring Cells in Gastric Cancer: The Higher Proportion, The Better Survival.

ABSTRACT:

Background

Due to the fact that the definition of gastric signet ring cell cancer (GSRC) was still controversial in the past decades, the prognosis affected by the proportion of signet ring cells within gastric cancer is uncertain. This study compared the clinicopathological features and prognosis of GSRC with the various proportions of signet ring cells.

Methods

We collected GSRC cases without metastasis who underwent curative (R0) resection between 2011 and 2018. Individuals who were in the low-proportion signet ring cell group (LSRC, <50%) were matched to those who were in the high-proportion signet ring cell group (HSRC, >50%) through propensity score matching (1:1). We used Cox proportional hazard regression to calculate the adjusted hazard ratios (HR) and 95% confidenc

SUBMITTER: Li Y 

PROVIDER: S-EPMC8630623 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature