Risk of Fracture Among Older Adults With Primary Hyperparathyroidism Receiving Parathyroidectomy vs Nonoperative Management.

ABSTRACT:

Importance

Primary hyperparathyroidism (PHPT) contributes to the development and progression of osteoporosis in older adults. The effectiveness of parathyroidectomy for reducing fracture risk in older adults is unknown.

Objective

To compare the incidence of clinical fracture among older adults with PHPT treated with parathyroidectomy vs nonoperative management.

Design, setting, and participants

This was a population-based, longitudinal cohort study of all Medicare beneficiaries with PHPT from 2006 to 2017. Multivariable, inverse probability weighted Cox proportional hazards and Fine-Gray competing risk regression models were constructed to determine the association of parathyroidectomy vs nonoperative management with incident fracture. Data analysis was conducted from

SUBMITTER: Seib CD 

PROVIDER: S-EPMC8630642 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature