Relationship Between Serum Amino Acid Levels and Bone Mineral Density: A Mendelian Randomization Study.

ABSTRACT:

Background

This study aimed to explore the association between serum amino acids (AAs) levels and bone mineral density (BMD).

Methods

We performed a two-sample Mendelian randomization (MR) analysis to analyze the associations between the levels of eight AAs and BMD values by using summary-level genome-wide association study (GWAS) data. We applied the MR Steiger filtering method and MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) global test to check for and remove single nucleotide polymorphisms (SNPs) that were horizontally pleiotropic. The associations were estimated with the inverse variance weighted (IVW), MR-Egger, weighted median and MR Robust Adjusted Profile Score (MR.RAPS) methods.

Results

Our study found that genetically increased isoleucine (Ile) [IVW:

SUBMITTER: Cui Z 

PROVIDER: S-EPMC8630695 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature