Per- and polyfluoroalkyl substance plasma concentrations and metabolomic markers of type 2 diabetes in the Diabetes Prevention Program trial.

ABSTRACT:

Background

Per- and polyfluoroalkyl substances (PFAS) are widely used chemicals, some of which have been linked to type 2 diabetes. We tested whether PFAS concentrations were cross-sectionally associated with metabolites previously shown to predict incident type 2 diabetes using the Diabetes Prevention Program (DPP), a trial of individuals at high risk of type 2 diabetes.

Methods

We evaluated 691 participants enrolled in the DPP with baseline measures of 10 PFAS (including total perfluorooctanesulfonic acid (PFOS), total perfluorooctanoic acid (PFOA), and Sb-PFOA [branched isomers of PFOA]) and 77 metabolites. We used log₂-transformed PFAS concentrations as exposures and standardized metabolite concentrations as outcomes in linear regression models adjusted for ag

SUBMITTER: Mitro SD 

PROVIDER: S-EPMC8630734 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature