Incidence of uterine leiomyoma in relation to urinary concentrations of phthalate and phthalate alternative biomarkers: A prospective ultrasound study.

ABSTRACT:

Background

Numerous studies suggest that some phthalates have adverse reproductive effects. However, literature on the association between phthalates and incidence of uterine leiomyomata (UL) is limited and inconsistent, with no existing prospective studies.

Objectives

We examined the association of urinary concentrations of phthalate and phthalate alternative biomarkers with UL incidence.

Methods

We conducted a case-cohort analysis within a subgroup of 754 participants in the Study of the Environment, Lifestyle, and Fibroids (SELF), a prospective cohort of premenopausal Black women aged 23-35 years who were recruited during 2010-2012. We quantified fourteen phthalates and two phthalate alternative [1,2-cyclohexane dicarboxylic acid, diisononyl ester (DINCH)] biomarke

SUBMITTER: Fruh V 

PROVIDER: S-EPMC8630749 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature