Dereplication of Bioactive Spirostane Saponins from Agave macroacantha.

ABSTRACT: A dereplication strategy using UPLC-QTOF/MS^E, the HMAI method, and NMR spectroscopy led to the identification of five main steroidal saponins (1-5), including three previously unknown compounds named macroacanthosides A-C (3-5), in a bioactive fraction of Agave macroacantha. The major saponins were isolated, and some of them together with the saponin-rich fraction were then evaluated for phytotoxicity on a standard target species, Lactuca sativa. The inhibition values exhibited by the pure compounds were confirmed to be in agreement with the phytotoxicity of the saponin-rich fraction, which suggests that the saponin fraction could be applied successfully as an agrochemical without undergoing any further costly and/or time-consuming purif

SUBMITTER: Duran AG 

PROVIDER: S-EPMC8630797 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature