Quantitative Difference in Solubility of Diastereomeric (²H/¹H)-Isotopomers.

ABSTRACT: Many achiral organic compounds become chiral by an isotopic substitution of one of the enantiotopic moieties in their structures. Although spectroscopic methods can recognize the molecular chirality due to an isotopic substitution, the effects of isotopically chiral compounds in enantioselective reactions have remained unsolved because the small chirality arises only from the difference between the number of neutrons in the atomic nuclei. The difference between the diastereomeric isotopomers of reactive sources should be the key to these effects. However, the energy difference between them is difficult to calculate, even using present computational methods, and differences in physical properties have not yet been reported. Here, we demonstrate that the small energy difference between the d

SUBMITTER: Kawasaki T 

PROVIDER: S-EPMC8630799 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature