Differential impact of antiretroviral therapy initiated before or during pregnancy on placenta pathology in HIV-positive women.

ABSTRACT:

Objective

To examine the association between timing of antiretroviral treatment (ART) initiation in HIV-infected women and placental histopathology.

Design

A nested substudy in a larger cohort of HIV-infected women which examined the association between ART status and birth outcomes.

Methods

Placentas (n = 130) were examined for histopathology from two ART groups: stable (n = 53), who initiated ART before conception and initiating (n = 77), who started ART during pregnancy [median (interquartile range) 15 weeks gestation (11-18)]. Using binomial regression we quantified associations between ART initiation timing with placental histopathology and pregnancy outcomes.

Results

One-third of all placentas were less than 10th percentile weight-for-gestation and there

SUBMITTER: Ikumi NM 

PROVIDER: S-EPMC8630811 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature